Graphene oxide coated capillary for chiral separation by CE

This article describes a new application of graphene oxide ( GO ) in CE based on the coating of fused silica capillary for chiral separation. The coated capillary was characterized by SEM , energy dispersive X‐ray spectroscopy, and Raman spectra. The results indicated that the capillary was coated with GO . Chiral separations were carried out in the GO ‐coated capillary for the ephedrine–pseudoephedrine ( E ‐ PE ) isomers and β‐methylphenethylamine (β‐Me‐PEA) isomers at the optimal buffer conditions without any chiral selector by CE . The precision and reproducibility of GO ‐coated capillary were investigated, and the RSD s of migration time ( n = 6) for the E ‐ PE isomers were 1.35–1.41%, and 0.97–3.50% for β‐Me‐ PEA isomers, respectively. The LOD for E ‐ PE isomers and β‐Me‐ PEA isomers was 3 μM and 18 μM, respectively.