Premium
Recent advances in the combination of capillary electrophoresis with mass spectrometry: From element to single‐cell analysis
Author(s) -
Klepárník Karel
Publication year - 2013
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201200488
Subject(s) - capillary electrophoresis , capillary electrochromatography , chromatography , mass spectrometry , capillary electrophoresis–mass spectrometry , proteomics , chemistry , computer science , electrospray ionization , biochemistry , gene
This overview deals with the latest development of electrophoresis in capillaries and microfluidic devices coupled to MS detection. A wide selection of relevant articles covers the literature published from January 2010 till June 2012 as a continuation of the review article on the same topic by Pantuckova et al. [ Electrophoresis 2011, 32 , 43–51]. Special attention is paid to the new improvements in instrumentation and methodology of three interfacing methods, ESI, matrix‐assisted desorption/ionization, and ICP. Representative examples illustrate applications in the proteomics, glycomics, metabolomics, biomarker research, forensics, pharmacology, food analysis and single‐cell analysis. The combinations of MS with capillary versions of electrochromatography, ITP, IEF, and micellar electrokinetic chromatography are not included.