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3 D numerical simulation of a C oulter counter array with analysis of electrokinetic forces
Author(s) -
Guo Jinhong,
Pui Tze Sian,
Rahman Abdur Rub Abdur,
Kang Yuejun
Publication year - 2013
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201200418
Subject(s) - electrokinetic phenomena , coulter counter , amplitude , particle (ecology) , voltage , current (fluid) , tracking (education) , throughput , particle counter , nanotechnology , physics , materials science , computer science , electrical engineering , engineering , optics , telecommunications , psychology , pedagogy , oceanography , wireless , aerosol , meteorology , microbiology and biotechnology , geology , biology
Coulter counters have played an important role in biological cell assays since their introduction decades ago. Several types of high throughput micro‐ C oulter counters based on lab‐on‐chip devices have been commercialized recently. In this paper, we propose a highly integrated micro‐ C oulter counter array working under low DC voltage. The real‐time electrical current change, including the pulse amplitude and width, of the micro‐ C oulter counter with novel structure is systematically investigated numerically. The major types of forces exerted on the particle in the micro‐ C oulter counter, including hydrodynamic force and electrokinetic force are quantitatively analyzed. The simulation in this study shows the pulse profile, such as width and amplitude, is affected by both particle size and the flow condition. The special cases of multiple particle aggregation and cross‐talk between neighboring channels are also considered for their effects on the electric current pulses. This simulation provides critical insight and guidance for developing next new generations of micro‐ C oulter counter.