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l ‐Lysine‐derived ionic liquids as chiral ligands of Z n(II) complexes used in ligand‐exchange CE
Author(s) -
Zhang Haizhi,
Qi Li,
Shen Ying,
Qiao Juan,
Mao Lanqun
Publication year - 2013
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201200388
Subject(s) - ligand (biochemistry) , chemistry , ionic liquid , amino acid , lysine , boric acid , ion exchange , medicinal chemistry , ammonium , stereochemistry , ion , crystallography , receptor , organic chemistry , catalysis , biochemistry
Amino acid ionic liquids ( AAIL s) with l ‐lysine ( l ‐ L ys) as anion were synthesized and applied as new chiral ligands in Z n(II) complexes for chiral ligand‐exchange CE . After effective optimization, baseline enantioseparation of seven pairs of dansylated amino acids was achieved with a buffer of 100.0 mM boric acid, 5.0 mM ammonium acetate, 3.0 mM ZnSO 4 , and 6.0 mM [ C 6 mim][ l ‐ L ys] at p H 8.2. To validate the unique behavior of AAIL s, a comparative study between the performance of Z n(II)‐ l ‐ L ys and Z n(II)‐[ C 6 mim][ l ‐ L ys] systems was conducted. In Z n(II)‐[ C 6 mim][ l ‐ L ys] system, it has been found that the improved chiral resolution could be obtained and the migration times of the three test samples were markedly prolonged. Then the separation mechanism was further discussed. The role of [ C 6 mim][ l ‐ L ys] indicated clearly that the synthesized AAIL s could be used as chiral ligands and would have potential utilization in separation science in future.