An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells | Zendy

Lee Jong Min | Zendy; Kim Jieun | Zendy; Kang Edward | Zendy; Lee SangHoon | Zendy; Chung Bong Geun | Zendy

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An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells

Author(s) -

Lee Jong Min,

Kim Jieun,

Kang Edward,

Lee SangHoon,

Chung Bong Geun

Publication year - 2011

Publication title -

electrophoresis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 158

eISSN - 1522-2683

pISSN - 0173-0835

DOI - 10.1002/elps.201100161

Subject(s) - embryonic stem cell , microbiology and biotechnology , stem cell , microfluidics , endothelial stem cell , cellular differentiation , cell culture , chemistry , biology , nanotechnology , materials science , in vitro , biochemistry , genetics , gene

We developed an integrated microfluidic culture device to regulate embryonic stem (ES) cell fate. The integrated microfluidic culture device consists of an air control channel and a fluidic channel with 4×4 micropillar arrays. We hypothesized that the microscale posts within the micropillar arrays would enable the control of uniform cell docking and shear stress profiles. We demonstrated that ES cells cultured for 6 days in the integrated microfluidic culture device differentiated into endothelial cells. Therefore, our integrated microfluidic culture device is a potentially powerful tool for directing ES cell fate.

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