Premium
CE‐MS for metabolomics: Developments and applications in the period 2008–2010
Author(s) -
Ramautar Rawi,
Mayboroda Oleg A.,
Somsen Govert W.,
de Jong Gerhardus J.
Publication year - 2011
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201000378
Subject(s) - metabolomics , interfacing , nanotechnology , chemistry , computer science , chromatography , materials science , computer hardware
This review provides an update of the state‐of‐the‐art of CE‐MS for metabolomic purposes, covering the scientific literature from July 2008 to June 2010. This review describes the different analytical aspects with respect to non‐targeted and targeted metabolomics and the new technological developments used in CE‐MS for metabolomics. The applicability of CE‐MS in metabolomics research is illustrated by examples of the analysis of biomedical and clinical samples, and for bacterial and plant extracts. The relevant papers on CE‐MS for metabolomics are comprehensively summarized in a table, including, e.g. information on sample type and pretreatment, and MS detection mode. Future considerations such as challenges for large‐scale and (quantitative) clinical metabolomics studies and the use of sheathless interfacing and different ionization techniques are discussed.