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Preparation and application of organic‐silica hybrid monolithic capillary columns
Author(s) -
Wu Minghuo,
Wu Ren'an,
Zhang Zhenbin,
Zou Hanfa
Publication year - 2011
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201000349
Subject(s) - capillary electrochromatography , materials science , hybrid material , silsesquioxane , capillary action , fabrication , extraction (chemistry) , reagent , monolithic hplc column , chromatography , sol gel , nanotechnology , chemistry , polymer , organic chemistry , composite material , pathology , medicine , alternative medicine
Organic‐silica hybrid monolithic columns have drawn more and more attention due to the ease of preparation and good mechanical stability in recent years. Many synthetic approaches have been developed and a variety of hybrid monolithic capillary columns have been prepared. The sol–gel process is well recognized in the fabrication of hybrid monolithic columns, which can be mainly classified as one‐step, acid/base two‐step procedures. The new approaches such as the “one‐pot” and nano‐scaled inorganic–organic hybrid reagent of polyhedral oligomeric silsesquioxane used as a cross‐linker have also emerged for the preparation of hybrid monolithic columns. The applications of the organic‐silica hybrid monolithic capillary columns for capillary electrochromatography, micro high‐performance liquid chromatography, solid‐phase micro‐extraction and enzymatic reactor etc. are included in this review.