Premium
Microfluidic gradient platforms for controlling cellular behavior
Author(s) -
Chung Bong Geun,
Choo Jaebum
Publication year - 2010
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201000137
Subject(s) - microfluidics , soft lithography , nanotechnology , extracellular matrix , axon guidance , fluidics , cell , cell migration , materials science , chemistry , microbiology and biotechnology , biology , axon , fabrication , medicine , biochemistry , alternative medicine , pathology , aerospace engineering , engineering
Concentration gradients play an important role in controlling biological and pathological processes, such as metastasis, embryogenesis, axon guidance, and wound healing. Microfluidic devices fabricated by photo‐ and soft lithography techniques can manipulate the fluidic flow and diffusion profile to create biomolecular gradients in a temporal and spatial manner. Furthermore, microfluidic devices enable the control of cell‐extracellular microenvironment interactions, including cell–cell, cell–matrix, and cell–soluble factor interaction. In this paper, we review the development of microfluidic‐based gradient devices and highlight their biological applications.