Premium
Analytical characterization of PEG polymers by MEKC
Author(s) -
Plata María R.,
Contento Ana M.,
Ríos Ángel
Publication year - 2010
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200900617
Subject(s) - dispersity , molar mass distribution , polymer , ethylene glycol , chemistry , oligomer , molecular mass , isocyanate , characterization (materials science) , peg ratio , analytical chemistry (journal) , mass fraction , chromatography , materials science , polymer chemistry , nanotechnology , organic chemistry , polyurethane , finance , economics , enzyme
Abstract Characterization of PEGs with average molecular masses of up to 2000 has been achieved using MEKC with UV detection. A rapid derivatization procedure with phenyl isocyanate using microwave radiation, in order to introduce chromophore groups in PEGs, has been developed involving a reaction time of 60 s. Different optimized conditions in accordance with the molecular weight have been studied to obtain the oligomer separation. The weight‐average molecular mass the number‐average molecular mass and the degree of polydispersity (molecular mass distribution) were calculated for the different PEGs obtaining similar results with those certified for standards. A good precision was obtained for characterizing the different oligomers. Ethylene glycol was used as the internal standard for the analysis of low‐molecular‐weight PEGs. The developed method was satisfactorily applied to the characterization of these polymers in several real samples, such as lubricant eye drops, toothpaste, tap water and eye make‐up remover.