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Field‐amplified sample injection‐micellar electrokinetic capillary chromatography for the analysis of bisphenol A, bisphenol F, and their diglycidyl ethers and derivatives in canned soft drinks
Author(s) -
GallartAyala Héctor,
Núñez Oscar,
Moyano Encarnación,
Galceran Maria Teresa
Publication year - 2010
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200900606
Subject(s) - chromatography , micellar electrokinetic chromatography , chemistry , bisphenol a , capillary electrophoresis , bisphenol , matrix (chemical analysis) , detection limit , epoxy , organic chemistry
Conditions were established for the separation and analysis of bisphenol A, bisphenol F, and their diglycidyl ethers by micellar electrokinetic capillary chromatography (MECC). Good resolution was obtained for all compounds, although in order to achieve the separation of ortho–ortho, ortho–para, and para–para isomers of bisphenol F diglycidyl ether (BFDGE), BFDGE·2H 2 O and BFDGE·2HCl, it was necessary to use a 25 μm id fused silica capillary. To increase sensitivity, a field‐amplified sample injection (FASI)‐MECC method was developed using 10 mM SDS solution as injection matrix and a 75 μm id fused silica capillary. Instrumental quality parameters such as LODs (<55 μg/L with standards), linearity ( r 2 >0.999), and run‐to‐run and day‐to‐day precisions (RSD values lower than 12.5%) were determined. Finally, the suitability of the FASI‐MECC method for the analysis of bisphenol A, bisphenol F, and their diglycidyl ethers in canned soft drinks was evaluated. Quantitation was performed by matrix‐matched calibration using a plastic‐bottled isotonic drink as matrix. The results showed that FASI‐MECC is an economic method for the screening and quantitation of these kinds of compounds in soft drink beverages, with no loss of reproducibility, and effective at concentrations lower than the specific migration level values established by the European Union.