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Metal(II)–ligand molar ratio dependence of enantioseparation of tartaric acid by ligand exchange CE with Cu(II) and Ni(II)– D ‐quinic acid systems
Author(s) -
Kodama Shuji,
Aizawa Senichi,
Taga Atsushi,
Yamashita Tomohisa,
Kemmei Tomoko,
Suzuki Kentaro,
Honda Yoshitaka,
Yamamoto Atsushi
Publication year - 2010
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200900596
Subject(s) - tartaric acid , quinic acid , chemistry , ligand (biochemistry) , molar ratio , enantiomer , molar , metal , inorganic chemistry , nuclear chemistry , catalysis , stereochemistry , organic chemistry , biochemistry , citric acid , medicine , receptor , dentistry
Enantioseparation of tartaric acid by ligand exchange CE with a Cu(II)– D ‐quinic acid system was studied. Racemic tartaric acid was enantioseparated by ligand exchange CE using BGEs containing relatively low Cu(II)– D ‐quinic acid molar ratios ranging from 1:1 to 1:3 and high molar ratios ranging from 1:8 to 1:12 but was not enantioseparated using BGEs with medium molar ratios ranging from 1:4 to 1:6. While the migration order of D ‐tartaric acid was prior to L ‐tartaric acid at the lower Cu(II)– D ‐quinic acid molar ratios, the enantiomer migration order was reversed at the higher molar ratios. These results were compared with those for Ni(II)– D ‐quinic acid system. The molar ratio dependence of enantiomer migration order can be attributed to a change in the coordination structure of Cu(II) ion with D ‐quinic acid.