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Organic solvents in CE
Author(s) -
Kenndler Ernst
Publication year - 2009
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200900180
Subject(s) - solvent , dispersion (optics) , capillary electrophoresis , organic solvent , chemical physics , reflection (computer programming) , chemistry , resolution (logic) , conductance , ionic bonding , ionic strength , electrophoresis , analytical chemistry (journal) , chemical engineering , organic chemistry , chromatography , condensed matter physics , optics , ion , computer science , physics , aqueous solution , engineering , artificial intelligence , programming language
In this contribution some fundamental aspects are discussed serving for a critical reflection and elucidation of the role of organic solvents in CE. The implications of the solvent on the parameters governing peak resolution are discussed based on the concepts describing migration and zone broadening in capillary zone electrophoresis. This discussion includes the solvent‐dependent influence of the ionic strength on the mobility. The role of the solvent on the plate number in case of the inevitable diffusional peak dispersion is outlined, and its effect on other peak broadening contributions is briefly examined. This paper also deals with the problems of conductance, applicable voltage and analysis time upon application of organic solvents, and tries to clarify some misunderstandings common in the literature.