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Progress in microchip enantioseparations
Author(s) -
Nagl Stefan,
Schulze Philipp,
Ludwig Martin,
Belder Detlev
Publication year - 2009
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200900153
Subject(s) - microfluidics , software portability , nanotechnology , computer science , biochemical engineering , process engineering , materials science , engineering , programming language
Advances in microfluidic chips for chiral separations from 2003 to early 2009 are discussed. Microchip‐based separation techniques promise higher speed, throughput, portability, less sample and reagent consumption, better environmental compatibility, reduced cost and the prospect of system integration. Microchip electrophoresis is the most promising technique for miniaturized enantioseparations and has been performed with a variety of designs and analytes, however, other formats such as microchip electrochromatography are also gaining in popularity. Microchip fabrication, chemistry and detection issues are critically discussed and highlighted. Integration of enantioseparation techniques into multifunctional microchips are currently a rapidly advancing area of research and methods are discussed that may eventually enable enantioseparations to be the part of a holistic chemical microchip.