Premium
Characterisation of mixed lithium dodecyl sulphate/lithium perfluorooctanesulphonate pseudo‐stationary phases in MEKC
Author(s) -
Varga András,
Huszár Mónika,
Dobos Zsófia,
Kiss Éva,
Horváth Anikó,
Idei Miklós
Publication year - 2009
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200800650
Subject(s) - lipophilicity , methylene , chemistry , selectivity , lithium (medication) , phase (matter) , partition coefficient , micelle , analyte , elution , homologous series , chromatography , analytical chemistry (journal) , aqueous solution , organic chemistry , medicine , endocrinology , catalysis
Lipophilicity and methylene selectivity of mixed pseudo‐stationary phases (PSPs) (containing lithium dodecyl sulphate (LDS) and lithium perfluorooctanesulphonate (LiPFOS) in different molar ratios) applied in MEKC have been investigated. Micellar proportion ( t prop,mic , a quantity expressing that how much time is spent by the analyte in the micellar phase related to its whole migration time), CLOGP 50 value (showing the value of hydrophobicity of a molecule spending exactly 50% of its migration time in the PSP) and methylene selectivity have been determined for different LDS/LiPFOS mixed phases. Values of the above‐mentioned parameters have been determined for analytes with different chemical structures (alkylbenzene and alkylphenone homologous series, alcohols). Good linear correlation was obtained between either the micellar proportion, CLOGP 50 , or methylene selectivity and the phase composition for the mixed phases. Lipophilicity and methylene selectivity of the mixed LDS/LiPFOS PSPs can be calculated and can continuously be changed by mixing the two single phases (LDS and LiPFOS) in the appropriate (and calculable) portion.