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Clinically relevant advances in on‐chip affinity‐based electrophoresis and electrochromatography
Author(s) -
Hou Chenlu,
Herr Amy E.
Publication year - 2008
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200800244
Subject(s) - electrokinetic phenomena , lab on a chip , electrochromatography , nanotechnology , point of care , computer science , microfluidics , capillary electrophoresis , computational biology , chromatography , capillary electrochromatography , chemistry , materials science , medicine , biology , nursing
Clinical and point‐of‐care disease diagnostics promise to play an important role in personalized medicine, new approaches to global health, and health monitoring. Emerging instrument platforms based on lab‐on‐a‐chip technology can confer perfomance advantages successfully exploited in electrophoresis and electrochromatography to affinity‐based electrokinetic separations. This review surveys lab‐on‐a‐chip diagnostic developments in affinity‐based electokinetic separations for quantitation of proteins, integration of preparatory functions needed for subsequent analysis of diverse biological samples, and initial forays into multiplexed analyses. The technologies detailed here underpin new clinical and point‐of‐care diagnostic strategies. The techniques and devices promise to advance translation of until now laborabory‐based sample preparation and analytical assays to near‐patient settings.