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Microfluidic differential resistive pulse sensors
Author(s) -
Wu Xudong,
Kang Yuejun,
Wang YaoNan,
Xu Dongyan,
Li Deyu,
Li Dongqing
Publication year - 2008
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200700912
Subject(s) - resistive touchscreen , materials science , volume (thermodynamics) , signal to noise ratio (imaging) , polystyrene , channel (broadcasting) , surface area to volume ratio , particle (ecology) , aperture (computer memory) , noise (video) , microfluidics , signal (programming language) , chip , pulse (music) , optics , optoelectronics , acoustics , nanotechnology , physics , electrical engineering , computer science , telecommunications , detector , composite material , engineering , artificial intelligence , image (mathematics) , oceanography , polymer , quantum mechanics , thermodynamics , programming language , geology
This study demonstrates an on‐chip resistive pulse‐sensing scheme with a design of symmetric mirror channels, which significantly reduces the noise and achieves better signal‐to‐noise ratio. Polystyrene particles of different sizes have been detected with the developed sensing scheme and a record low volume ratio of the particle to the sensing channel, or 0.0004%, has been detected with particles of 520 nm in diameter in a sensing aperture of 50×16×20 μm 3 . This volume ratio is about ten times lower than the lowest volume ratio reported in the literature including that specified for commercial Coulter counters.