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A new interface used to couple capillary electrophoresis with an inductively coupled plasma mass spectrometry for speciation analysis
Author(s) -
Yang GuiDi,
Xu XueQin,
Wang Wei,
Xu LiangJun,
Chen GuoNan,
Fu FengFu
Publication year - 2008
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200700849
Subject(s) - capillary electrophoresis , chemistry , inductively coupled plasma mass spectrometry , detection limit , mass spectrometry , analytical chemistry (journal) , chromatography , analyte , capillary action , inductively coupled plasma , nebulizer , electrophoresis , plasma , materials science , medicine , physics , quantum mechanics , anesthesia , composite material
In this work, a novel and high‐efficiency interface has been developed in coupling CE with inductively coupled plasma MS (ICPMS). The interface completely avoids laminar flow in CE capillary caused by the suction of nebulizer, and can be easily and stably operated at room temperature with high analyte transport efficiency to ICPMS. The new interface has a liquid dead volume smaller than 5 nL, which was much smaller than those (65–2500 µL) reported previously for other interfaces. All above features led to a higher sensitivity and a better electrophoretic resolution for CE‐ICPMS coupled with this new interface. With the help of this new interface, we have successfully separated and determined five species of arsenic, As(III), As(V), monomethylarsonic acid, dimethylarsinic acid and p ‐aminophenylarsonic acid using CE‐ICPMS within 11 min with a detection limit of 0.046–0.075 ng/mL and an RSD of 2–6% ( n = 6).