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The role of cyclodextrins in chiral capillary electrophoresis
Author(s) -
Juvancz Zoltán,
Kendrovics Rita Bodáné,
Iványi Róbert,
Szente Lajos
Publication year - 2008
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200700657
Subject(s) - capillary electrophoresis , enantiomer , combinatorial chemistry , chemistry , selectivity , cyclodextrin , computational chemistry , chromatography , organic chemistry , catalysis
The members of the enantiomeric pairs frequently show rather different biological effects, so their chiral selective synthesis, pharmacological studies and analysis are necessary. CE has unique advantages in chiral analysis. The most frequently used chiral selectors are CDs in this field. This paper gives a short view on the advantages on CE in direct chiral separations, emphasizing the role of CDs. The reason for the broad selectivity spectra of CDs is discussed in detail. The physical background of chiral selective separations is briefly shown in CE. Their interaction mechanisms are shortly defined. The general trend of their use is statistically evaluated. Most frequently used CDs and CD derivatives are characterized. Advantages of ionizable CDs and single‐isomer derivatives are shown. The general trend of their use is established.