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Enantiomeric separations of binaphthyl derivatives by capillary electrophoresis using N ‐(2‐hydroxydodecyl)‐ L ‐threonine as chiral selector: Effect of organic additives
Author(s) -
Ghosh Arjun,
Dey Joykrishna
Publication year - 2008
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200700638
Subject(s) - enantiomer , chemistry , acetonitrile , capillary electrophoresis , methanol , selectivity , chromatography , resolution (logic) , pulmonary surfactant , racemic mixture , medicinal chemistry , organic chemistry , catalysis , artificial intelligence , computer science , biochemistry
The chiral selectivity of a novel amphiphile, N ‐(2‐hydroxydodecyl)‐ L ‐threonine (2‐HDT), was evaluated for enantiomeric resolution of three binaphthyl derivatives (±)−1,1′‐bi‐2‐naphthol, (±)−1,1′‐binaphthyl‐2,2′‐diamine, and (±)−1,1′‐binaphthyl‐2,2′‐diylhdrogen phosphate (BNP) by micellar EKC. The effects of three organic modifiers, methanol, isopropanol, and acetonitrile, on the separations of enantiomers of these compounds were investigated. Separation of enantiomers could be achieved in relatively dilute solutions of the pure surfactant. However, best separations of enantiomers were obtained only in the presence of 10% v/v acetonitrile. Enantiomeric impurity in nonracemic mixtures of R ‐ and S ‐forms of BNP was determined.