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Sensitive chiral analysis by CE: An update
Author(s) -
SánchezHernández Laura,
Crego Antonio Luis,
Marina María Luisa,
GarcíaRuiz Carmen
Publication year - 2007
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200700531
Subject(s) - capillary electrophoresis , enantiomer , detection limit , chromatography , sensitivity (control systems) , computer science , chemistry , stereochemistry , engineering , electronic engineering
A general view of the different strategies used in the last years to enhance the detection sensitivity in chiral analysis by CE is provided in this article. With this purpose and in order to update the previous review by García‐Ruiz et al., the articles appeared on this subject from January 2005 to March 2007 are considered. Three were the main strategies employed to increase the detection sensitivity in chiral analysis by CE: (i) the use of off‐line sample treatment techniques, (ii) the employment of in‐capillary preconcentration techniques based on electrophoretic principles, and (iii) the use of alternative detection systems to the widely employed on‐column UV–Vis absorption detection. Combinations of two or three of the above‐mentioned strategies gave rise to adequate concentration detection limits up to 10 −10 M enabling enantiomer analysis in a variety of real samples including complex biological matrices.