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Liquid‐core waveguide in CE
Author(s) -
Okada Tetsuo
Publication year - 2007
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200700102
Subject(s) - capillary action , absorption (acoustics) , sensitivity (control systems) , fluorescence , core (optical fiber) , waveguide , materials science , capillary electrophoresis , scattering , optics , computer science , optoelectronics , electronic engineering , physics , chemistry , chromatography , engineering , composite material
Liquid‐core waveguide (LCW) brings about several advantages in CE. This review discusses some aspects of fundamental and practical importance involved in this method. Sensitivity in absorption and fluorescence detection is in general improved by more than one order of magnitude over usual crossbeam detection arrangements; the improvements come from the long light path in absorption detection and low light scattering in fluorescence detection. Versatile instrumental arrangements are another advantage of LCW in CE, leading to several detection schemes, some of which provide information that is not gained by usual capillary‐end crossbeam detection, e.g . whole‐capillary imaging, simultaneous monitoring of multicapillary separation, and kinetic evaluation. The high potential and perspectives of LCW in CE are discussed based on the state‐of‐the‐art developments.