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Bulk modification of PDMS microchips by an amphiphilic copolymer
Author(s) -
Xiao Yan,
Yu XiaoDong,
Xu JingJuan,
Chen HongYuan
Publication year - 2007
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200700024
Subject(s) - amphiphile , materials science , copolymer , fabrication , ethylene glycol , peg ratio , chemical engineering , adsorption , contact angle , nanotechnology , polymer , chemistry , organic chemistry , composite material , medicine , alternative medicine , finance , pathology , economics , engineering
A simple and rapid bulk‐modification method based on adding an amphiphilic copolymer during the fabrication process was employed to modify PDMS microchips. Poly(lactic acid)–poly(ethylene glycol) (PLA–PEG) was used as the additive substance. Compared to the native PDMS microchips, both the contact angle and the EOF of the bulk‐modified PDMS microchips decreased. The effects of the additive loading and the pH on the EOF were investigated in detail. The bulk‐modified PDMS microchips exhibited reproducible and stable EOF behavior. The application of the bulk‐modified PDMS microchips was also studied and the results indicated that they could be successfully used to separate amino acids and to suppress protein adsorption.