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Screening for biomarkers in plasma from patients with gangrenous and phlegmonous appendicitis using CE and CEC in combination with MS
Author(s) -
Johannesson Nina,
Olsson Louise,
Bäckström Daniel,
Wetterhall Magnus,
Danielsson Rolf,
Bergquist Jonas
Publication year - 2007
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200600606
Subject(s) - appendicitis , chemometrics , medicine , chemistry , chromatography , surgery
Abstract Today a high degree of “false” appendicitis diagnoses are occurring. In this study, a screening experiment of biomarkers of two different kinds of appendicitis, gangrenous and phlegmonous, were conducted with CE and CEC coupled to MS. Plasma samples were obtained from patients pre‐ and post‐surgery. A large amount of data was generated to be able to compare them, and chemometrics tools were utilized to visualize the differences. Indicative patterns were found for both pre‐ and post‐surgery of the two types of inflammation as well as between them. The divergences were traced back to the MS peaks obtained in the CE‐ and CEC‐MS setups as possible biomarkers for the two forms of appendicitis.