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Rapid characterization of alkylpolyphosphonates by CZE with indirect photometric and mass spectrometric detection
Author(s) -
BernabéZafón Virginia,
MicóTormos Anna,
SimóAlfonso Ernesto F.,
RamisRamos Guillermo
Publication year - 2007
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200600311
Subject(s) - phosphonate , chemistry , chromatography , mass spectrum , salt (chemistry) , methylene , mass spectrometry , medicinal chemistry , organic chemistry
Methods for the rapid characterization of industrial alkylpolyphosphonates (APPs) by infusion MS and CZE with indirect photometric (IPD) and MS detection are described. Technical‐grade APPs, including alkylaminepolyphosphonates with 3–5 phosphonate groups and different hydrocarbon skeletons, hydroxyethyl‐amino‐ bis (methylenephosphonic acid), hydroxyethylidene‐diphosphonic acid, and 2‐phosphonobutane‐1,2,4‐tricarboxylic acid, were examined. A 10 mM solution of adenosine triphosphate disodium salt at pH 2.2 was used as BGE. The nominal compounds of the industrial APPs and their impurities were well resolved in less than 15 min. The peaks were identified by using extracted ion electropherograms, which were obtained at the m/z values indicated by the peaks of the infusion spectra. Low concentrations of esters, anhydrides, and APPs having different hydrocarbon skeletons compared to nominal compounds, and lacking phosphonate and methylene‐phosphonate groups with respect to them, were found. Also, hydroxyethyl‐amino bis (methylenephosphonic acid) contained an intramolecular ester at a concentration close to that of the nominal compound. Application of CZE‐IPD and CZE‐MS to the quality control of industrial APPs, and of CZE‐MS to the identification and characterization of APPs in cleaning products, was demonstrated.