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( S )‐Ibuprofen‐imprinted polymers incorporating γ‐methacryloxypropyl‐trimethoxysilane for CEC separation of ibuprofen enantiomers
Author(s) -
Deng QiLiang,
Lun ZhiHong,
Gao RuYu,
Zhang LiHua,
Zhang WeiBing,
Zhang YuKui
Publication year - 2006
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200600180
Subject(s) - ibuprofen , enantiomer , chemistry , molecularly imprinted polymer , chromatography , organic chemistry , catalysis , selectivity , pharmacology , medicine
In this report, a novel preparation method of molecularly imprinted polymers (MIPs) for CEC was developed. Molecularly imprinted monolithic columns for ( S )‐ibuprofen were prepared and evaluated, in which charged entities responsible for establishing EOF have been derived from γ‐methacryloxypropyltrimethoxysilane (γ‐MAPS), which was hydrolyzed following copolymerization with 4‐vinylpyridine (4‐VPY) and ethylene glycol dimethacrylate (EDMA). The EOF and molecular recognition of the stationary phase were investigated in aqueous and nonaqueous media, respectively. The experimental results indicated that the material showed a reasonably stable EOF and the prepared separation materials were capable of separating racemic ibuprofen, a task that could not be accomplished by MIPs prepared in parallel, using methacrylic acid (MAA) as a functional monomer. The efficiency at pH 3.2 for the first‐eluted enantiomer and the last‐eluted enantiomer (the imprinted analyte) were 128 700 and 2100 plates/m, respectively.