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Capillary electrophoresis for the analysis of small‐molecule pharmaceuticals
Author(s) -
Altria Kevin,
Marsh Alex,
Sängervan de Griend Cari
Publication year - 2006
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200600030
Subject(s) - capillary electrophoresis , small molecule , chemistry , electrolyte , molecule , electrophoresis , enantiomer , chromatography , combinatorial chemistry , organic chemistry , biochemistry , electrode
This paper reviews the application of CE to the analysis of small‐molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter‐ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and p K a of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.