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CE‐based analysis of hemoglobin and its applications in clinical analysis
Author(s) -
Wang Junhua,
Zhou Shilai,
Huang Weihua,
Liu Yanming,
Cheng Cheng,
Lu Xin,
Cheng Jieke
Publication year - 2006
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200500833
Subject(s) - chemiluminescence , hemoglobin variants , capillary electrophoresis , hemoglobin , chromatography , microfluidics , resolution (logic) , chemistry , high resolution , nanotechnology , computer science , materials science , biochemistry , artificial intelligence , remote sensing , geology
This review focuses on the developments and trends in CE including CIEF, CZE, MEKC, two‐dimensional conjunction of CIEF‐capillary gel electrophoresis, and MEKC‐CZE on microfluidic devices coupled to different detection approaches, such as UV absorbance, LIF, MS, and chemiluminescence etc. for performing analysis of hemoglobin (Hb), also with an emphasis on its applications in clinical analysis. Analysis of human Hb is of important clinical sense for numerous hemoglobinopathies associated with the congenital defects and abnormal contents of Hb. The diversiform modes render CE a comprehensive primary clinical tool for Hb analysis, which is rapid, sensitive, high‐resolution, and not labor‐intensive.