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Capillary electrophoresis at the omics level: Towards systems biology
Author(s) -
Babu C. V. Suresh,
Song Eun Joo,
Babar Sheikh Md. Enayetul,
Wi Mun Hyung,
Yoo Young Sook
Publication year - 2006
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200500511
Subject(s) - capillary electrophoresis , biology , computational biology , omics , chromatography , chemistry , bioinformatics , microbiology and biotechnology
Emerging systems biology aims at integrating the enormous amount of existing omics data in order to better understand their functional relationships at a whole systems level. These huge datasets can be obtained through advances in high‐throughput, sensitive, precise, and accurate analytical instrumentation and technological innovation. Separation sciences play an important role in revealing biological processes at various omic levels. From the perspective of systems biology, CE is a strong candidate for high‐throughput, sensitive data generation which is capable of tackling the challenges in acquiring qualitative and quantitative knowledge through a system‐level study. This review focuses on the applicability of CE to systems‐based analytical data at the genomic, transcriptomic, proteomic, and metabolomic levels.