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Chip‐based microfluidic devices coupled with electrospray ionization‐mass spectrometry
Author(s) -
Sung WangChou,
Makamba Honest,
Chen ShuHui
Publication year - 2005
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200410346
Subject(s) - miniaturization , microfluidics , electrospray , electrospray ionization , mass spectrometry , nanotechnology , extractive electrospray ionization , materials science , microfluidic chip , chip , chromatography , analytical chemistry (journal) , chemistry , computer science , sample preparation in mass spectrometry , telecommunications
We present the current status of the development of microfluidic devices fabricated on different substrates for coupling with electrospray ionization‐mass spectrometry (ESI‐MS). Until now, much success has been gained in fabricating the ESI chips, which show better performances due to miniaturization when compared with traditional methods. Integration of multiple steps for sample preparation and ESI sample introduction, however, remains a great challenge. This review covers the main technical development of electrospray device that were published from 1997 to 2004. This article does not attempt to be exclusive. Instead, it focuses on the publications that illustrated the breath of the development and applications of microchip devices for MS‐based analysis.