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A one‐dimensional transient model of electrical field flow fractionation
Author(s) -
Biernacki Joseph J.,
Vyas Naitik
Publication year - 2005
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200406149
Subject(s) - transient (computer programming) , fractionation , electric field , constant (computer programming) , field (mathematics) , time constant , mechanics , field flow fractionation , channel (broadcasting) , square wave , voltage , flow (mathematics) , resolution (logic) , materials science , analytical chemistry (journal) , chemistry , chromatography , computer science , electrical engineering , physics , mathematics , telecommunications , engineering , quantum mechanics , artificial intelligence , pure mathematics , programming language , operating system
A well‐developed classical theory is available for constant‐voltage electrical field flow fractionation (EFFF). Recent experimental research, however, has demonstrated that pulsed fields may enhance retention in some cases. A generalized mathematical approach is presented for the prediction of retention ratios for any field type, pulsed or constant. The methodology is applied and demonstrated for a square wave protocol. Complex concentration profiles arise wherein particles are focused either towards the walls or into the channel center. The computational results indicate that pulsation can either increase retention time or decrease retention time by manipulating the effective electric field and suggest that separation resolution may also be improved.