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Determination of some acidic drugs in surface and sewage treatment plant waters by capillary electrophoresis‐electrospray ionization‐mass spectrometry
Author(s) -
Macià Alba,
Borrull Francesc,
Calull Marta,
Aguilar Carme
Publication year - 2004
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200406067
Subject(s) - chemistry , chromatography , capillary electrophoresis , electrospray ionization , solid phase extraction , electrospray , mass spectrometry , capillary electrophoresis–mass spectrometry , detection limit , extraction (chemistry)
We describe an analytical method involving solid‐phase extraction (SPE) and capillary zone electrophoresis‐electrospray ionization‐mass spectrometry (CZE‐ESI‐MS) for determining some pharmaceutical compounds – naproxen, clofibric acid and bezafibrate – in real water samples. The electrospray parameters were optimized to maximize sensitivity. When a mixed aqueous‐organic solvent and CZE‐ESI‐MS were used to analyze these drugs in water samples, the capillary was coated with hexadimethrin bromide (HDB) to permanently reverse the EOF. The method was developed from off‐line SPE‐CZE‐MS and was validated with surface water. The detection limits were 100 ng·L ‐1 for all analytes. The method was applied to analyze water samples from the influent and effluent of a sewage treatment plant. A liquid‐liquid extraction step was required before SPE, and the compounds studied were found, some of them between detection and quantification limits.