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Development and validation of a capillary electrophoresis method for the enantiomeric purity determination of SLV307, a basic potential antipsychotic compound
Author(s) -
Muijselaar Pim G.,
Lammers Norbert G. F. M.,
Gerding Thijs K.
Publication year - 2004
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200406022
Subject(s) - capillary electrophoresis , enantiomer , chromatography , antipsychotic , chemistry , computer science , stereochemistry , schizophrenia (object oriented programming) , programming language
A capillary electrophoresis method for the enantiomeric purity determination of SLV307, a basic potential antipsychotic compound, has been developed and validated. It is shown that the presence of the eutomer in the sample solution may have a significant effect on the peak shape of the distomer, due to electrodispersion. The method is shown to give good performance with respect to the validation parameters specificity, linearity, accuracy, precision, determination limits, stability of solutions, and robustness of extraction.