Premium
Heptakis(6‐amino‐6‐deoxy)‐β‐cyclodextrin as a chiral selector for the separation of anionic analyte enantiomers by capillary electrophoresis
Author(s) -
Budanova Natalia,
Shapovalova Elena,
Lopatin Sergei,
Varlamov Valery,
Shpigun Oleg
Publication year - 2004
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200405970
Subject(s) - capillary electrophoresis , enantiomer , analyte , cyclodextrin , chromatography , chemistry , electrophoresis , stereochemistry
A hepta‐substituted β‐cyclodextrin bearing seven amino groups, heptakis(6‐amino‐6‐deoxy)‐β‐cyclodextrin (per‐6‐NH 2 ‐β‐CD) was successfully used as a chiral selector for the enantioseparation of different anionic analytes. The running buffer pH and chiral selector concentration were the studied parameters crucial in achieving the maximum possible enantioresolution. Enantiomeric separation of a mixture of seven carboxybenzyl‐amino acids was achieved in 24 min. Excellent resolution was obtained for carboxybenzyl‐tryptophan ( R s = 11.2).