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Single‐isomer sulfated α‐cyclodextrins for capillary electrophoresis. Part 2. Hexakis(6‐ O ‐sulfo)‐α‐cyclodextrin: Synthesis, analytical characterization, and initial screening tests
Author(s) -
Li Shulan,
Vigh Gyula
Publication year - 2004
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200405863
Subject(s) - cyclodextrin , chemistry , capillary electrophoresis , analyte , enantiomer , sulfation , electrolyte , chromatography , electrophoresis , beta cyclodextrins , sodium , medicinal chemistry , organic chemistry , biochemistry , electrode
The second member of the family of single‐isomer sulfated α‐cyclodextrins, the sodium salt of hexakis(6‐ O ‐sulfo)‐α‐cyclodextrin (HxS), has been synthesized, analytically characterized, and used as the resolving agent for the capillary electrophoretic separation of the enantiomers of nonionic, weak‐acid and weak‐base analytes present in our initial screening kit. HxS interacted less strongly with many of the analytes tested than the larger‐ring analogs, heptakis(6‐ O ‐sulfo)‐β‐cyclodextrin (HS) and octakis(6‐ O ‐sulfo)‐γ‐cyclodextrin (OS). For some of the analytes, the separation selectivities obtained with HxS were complementary to those observed with hexakis(2,3‐di‐ O ‐acetyl‐6‐ O ‐sulfo)‐α‐cyclodextrin (HxDAS), HS, and OS. For all analytes, the effective mobilities and separation selectivities as a function of the background electrolyte concentration of HxS followed the trends that were found for HxDAS, HS, and OS.