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Chiral separation of 3,4‐methylenedioxymeth‐ amphetamine and related compounds in clandestine tablets and urine samples by capillary electrophoresis/fluorescence spectroscopy
Author(s) -
Huang YuSan,
Liu JuTsung,
Lin LiChang,
Lin ChengHuang
Publication year - 2003
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200390128
Subject(s) - capillary electrophoresis , chromatography , chemistry , electrophoresis , metabolite , mass spectrometry , urine , amphetamine , gas chromatography , fluorescence spectroscopy , cyclodextrin , fluorescence , biochemistry , physics , quantum mechanics , neuroscience , dopamine , biology
The R ‐(–)‐ and S ‐(+)‐isomers of 3,4‐methylenedioxymethamphetamine (MDMA) and its metabolite 3,4‐methylenedioxyamphetamine (MDA) were prepared, identified by gas chromatography/mass spectrometry (GC/MS) and then used as standards in a series of capillary electrophoresis (CE) experiments. Using these R ‐(–)‐ and S ‐(+)‐isomers, the distribution of ( RS )‐MDA and ( RS )‐MDMA stereoisomers in clandestine tablets and suspect urine samples were identified. Several electrophoretic parameters, such as the concentration of β‐cyclodextrin used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.