Fenofibrate and fenofibric acid analysis by capillary electrophoresis | Zendy

Shihabi Zak K. | Zendy

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Fenofibrate and fenofibric acid analysis by capillary electrophoresis

Author(s) -

Shihabi Zak K.

Publication year - 2004

Publication title -

electrophoresis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 158

eISSN - 1522-2683

pISSN - 0173-0835

DOI - 10.1002/elps.200305849

Subject(s) - capillary electrophoresis , chromatography , chemistry , sodium dodecyl sulfate , micellar electrokinetic chromatography , fenofibrate , electrokinetic phenomena , analyte , pharmacology , medicine

A capillary electrophoresis method has been developed to measure fenofibrate in capsules based on micellar electrokinetic capillary chromatography with detection at 280 nm using a borate buffer containing sodium dodecyl sulfate (SDS). However, the metabolite of this drug (fenofibric acid) in serum and whole blood was analyzed by capillary zone electrophoresis (CZE) in a borate‐carbonate buffer using acetonitrile stacking. The analysis is rapid, < 7 min with no interferences. Incubation of fenofibrate in whole blood caused hydrolysis of the ester bond with the release of fenofibric acid.

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