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Study of the development of thermoresistance in human pancreatic carcinoma cell lines using proteome analysis
Author(s) -
Poland Julia,
Urbani Andrea,
Lage Hermann,
Schnölzer Martina,
Sinha Pranav
Publication year - 2004
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200305698
Subject(s) - proteome , proteomics , cell culture , phenotype , biology , computational biology , pancreatic cancer , in vitro , cancer research , microbiology and biotechnology , bioinformatics , cancer , gene , genetics
In order to find candidate proteins that are potentially associated with the thermoresistant phenotype in combination with drug resistance, we analyzed the differential protein expression in vitro in the human pancreatic cancer cell line EPP85‐181‐P and classical and atypical multidrug‐resistant variants and their thermoresistant counterparts using proteomics. This study identifies sets of proteins that may lead to the development of thermoresistance. These results provide a fundamental basis to elucidate the molecular mechanism of thermoresistance and chemoresistance phenomena that may assist the therapy of inoperable cancers.