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Surface modification of poly(dimethylsiloxane) microchannels
Author(s) -
Makamba Honest,
Kim Jin Ho,
Lim Kwanseop,
Park Nokyoung,
Hahn Jong Hoon
Publication year - 2003
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200305627
Subject(s) - microchannel , microfluidics , surface modification , adsorption , nanotechnology , materials science , protein adsorption , aqueous solution , chromatography , chemical engineering , chemistry , organic chemistry , engineering
This review looks at the efforts that are being made to modify the surface of poly(dimethylsiloxane) (PDMS) microchannels, in order to enhance applicability in the field of microfluidics. Many surface modifications of PDMS have been performed for electrophoretic separations, but new modifications are being done for emerging applications such as heterogeneous immunoassays and cell‐based bioassays. These new modification techniques are powerful because they impart biospecificity to the microchannel surfaces and reduce protein adsorption. Most of these applications require the use of aqueous or polar solvents, which makes surface modification a very important topic.