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Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples
Author(s) -
Macià Alba,
Borrull Francesc,
Aguilar Carme,
Calull Marta
Publication year - 2003
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200305542
Subject(s) - capillary electrophoresis , chromatography , stacking , chemistry , capillary action , sensitivity (control systems) , solid phase extraction , solvent , extraction (chemistry) , volume (thermodynamics) , methanol , analytical chemistry (journal) , nonsteroidal , materials science , pharmacology , physics , organic chemistry , quantum mechanics , electronic engineering , engineering , composite material , medicine
Large‐volume sample stacking using the electroosmotic flow (EOF) pump (LVSEP) has been used to analyze some nonsteroidal anti‐inflammatory drugs (NSAIDs) in water samples. With methanol as the run buffer solvent to suppress the EOF, sensitivity was enhanced by 80–100‐fold. The sample for the analysis of real water sample was pretreated by solid‐phase extraction (SPE). When the method was based on off‐line SPE‐LVSEP‐CE, sensitivity improved by as much as 1000 times.