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Multiple injection techniques for microfluidic sample handling
Author(s) -
Fu LungMing,
Yang RueyJen,
Lee GwoBin,
Pan YuJen
Publication year - 2003
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.200305528
Subject(s) - electrokinetic phenomena , microfluidics , sample (material) , throughput , mixing (physics) , materials science , flow (mathematics) , nanotechnology , analytical chemistry (journal) , computer science , chromatography , chemistry , mechanics , physics , telecommunications , quantum mechanics , wireless
This paper presents an experimental and numerical investigation into electrokinetic focusing flow injection for bioanalytical applications on 1× N ( i.e. , 1 sample inlet port and N outlet ports) and M × N ( i.e. , M sample inlet ports and N outlet ports) microfluidic chips. A novel device is presented which integrates two important microfluidic phenomena, namely electrokinetic focusing and valveless flow switching within multiported microchannels. The study proposes a voltage control model which achieves electrokinetic focusing in a prefocusing sample injection system and which allows the volume of the sample to be controlled. Using the developed methods, the study shows how the sample may be prefocused electrokinetically into a narrow stream prior to being injected continuously into specified outlet ports. The microfluidic chips presented within this paper possess an exciting potential for use in a variety of techniques, including high‐throughput chemical analysis, cell fusion, fraction collection, fast sample mixing, and many other applications within the micrototalanalysis systems field.