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Capillary electrophoresis interfaced to inductively coupled plasma mass spectrometry for element selective detection in arsenic speciation
Author(s) -
Michalke Bernhard,
Schramel Peter
Publication year - 1998
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150191229
Subject(s) - arsenobetaine , capillary electrophoresis , inductively coupled plasma mass spectrometry , detection limit , chemistry , arsenic , chromatography , mass spectrometry , analytical chemistry (journal) , organic chemistry
A method is presented to separate and detect six arsenic species by capillary electrophoresis (CE) interfaced to inductively coupled plasma mass spectrometry (ICP‐MS). CE was used as a highly resolving separation system, whereas ICP‐MS served as an element selective detector providing low detection limits. The special mode of operation included sample stacking and a differentiation of separation and detection. This provided separation and detection of six As species, uncharged and anionic, to be monitored within a single run. Detection limits were calculated according to IUPAC recommendation at 15 μg As/L for As (III), dimethyl arsinic acid (DA), monomethyl arsonic acid (MA) and As (V), or 65 μg As/L for arsenobetaine (AsB) and arsenocholine (AsC). Investigations were focused on possibly occurring interferences, e.g. , ArCl + interference at the monoisotope 75 As. Finally, real samples from biomedical field (urine) and environmental field (sewage sludge) were analyzed.