Premium
European functional analysis network (EUROFAN) and the functional analysis of the Saccharomyces cerevisiae genome (minireview)
Author(s) -
Dujon Bernard
Publication year - 1998
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150190427
Subject(s) - saccharomyces cerevisiae , proteome , functional genomics , yeast , genome , transcriptome , computational biology , biology , genomics , model organism , gene , mutant , genetics , gene expression
Abstract Less than two yeras after the sequence of its genome was completed, the baker's yeast, Saccharomyces cerevisiae , is a leading organism in the rapidly growing field of functional genomics. Two thousands novel protein coding genes, nearly all of them “orphans”, have already been disrupted by the coordinated efforts of a large consortium of European laboratories, EUROFAN, and other initiatives. The mutants are submitted to many specialized functional assays, and studies are performed in parallel at the transcriptome and the proteome levels. With a central repository of mutant yeast strains, and a centralized database, EUROFAN lays the foundations for the future of genomics with yeast serving both as a model and a tool.