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Mycobacterial genome structure (minireview)
Author(s) -
Philipp Wolfgang J.,
Schwartz David C.,
Telenti Amalio,
Cole Stewart T.
Publication year - 1998
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150190418
Subject(s) - mycobacterium leprae , genome , mycobacterium bovis , biology , mycobacterium tuberculosis , bacilli , mycobacterium , whole genome sequencing , mycobacterium tuberculosis complex , tuberculosis , microbiology and biotechnology , genetics , virology , bacteria , leprosy , gene , medicine , immunology , pathology
Genome maps have been constructed for the mycobacterial pathogens Mycobacterium leprae and Mycobacterium tuberculosis , as well as for the attenuated vaccine strain Mycobacterium bovis BCG Pasteur. While the chromosomes of M. tuberculosis and M. bovis BCG Pasteur show extensive conservation at the grosslevel, comparison with M. leprae revealed a high degree of diversification, with a mosaic‐like pattern apparent. The ordered libraries of M. tuberculosis and M. leprae produced during the course of these studies played a central role in the genome sequencing projects of these two bacilli, showing the utility of this approach for systematic sequencing of bacterial genomes.