Resolution of the diastereomers of a large synthetic peptide by capillary electrophoresis using nonionic surfactants | Zendy

Gilges Martin | Zendy; Hadley Mark | Zendy

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Resolution of the diastereomers of a large synthetic peptide by capillary electrophoresis using nonionic surfactants

Author(s) -

Gilges Martin,

Hadley Mark

Publication year - 1997

Publication title -

electrophoresis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 158

eISSN - 1522-2683

pISSN - 0173-0835

DOI - 10.1002/elps.1150181536

Subject(s) - diastereomer , capillary electrophoresis , chromatography , chemistry , resolution (logic) , peptide , capillary action , electrophoresis , materials science , stereochemistry , biochemistry , computer science , artificial intelligence , composite material

A capillary electrophoretic method was developed for the determination of the diastereomeric composition of the bradykinin B 2 antagonist, SB‐238592‐DB. The nonionic surfactant Brij 35 was demonstrated to be suitable for the baseline resolution of the three diastereoisomers of SB‐238592‐DB in the presence of a low pH phosphate buffer and small volume percentages of acetonitrile.

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