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Resolution of the diastereomers of a large synthetic peptide by capillary electrophoresis using nonionic surfactants
Author(s) -
Gilges Martin,
Hadley Mark
Publication year - 1997
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150181536
Subject(s) - diastereomer , capillary electrophoresis , chromatography , chemistry , resolution (logic) , peptide , capillary action , electrophoresis , materials science , stereochemistry , biochemistry , computer science , artificial intelligence , composite material
A capillary electrophoretic method was developed for the determination of the diastereomeric composition of the bradykinin B 2 antagonist, SB‐238592‐DB. The nonionic surfactant Brij 35 was demonstrated to be suitable for the baseline resolution of the three diastereoisomers of SB‐238592‐DB in the presence of a low pH phosphate buffer and small volume percentages of acetonitrile.