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Chemiluminescence detection in capillary electrophoresis
Author(s) -
Staller Tracy D.,
Sepaniak Michael J.
Publication year - 1997
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150181219
Subject(s) - chemiluminescence , capillary electrophoresis , chromatography , detector , detection limit , chemistry , analytical chemistry (journal) , capillary action , sample (material) , yield (engineering) , materials science , computer science , telecommunications , metallurgy , composite material
Capillary electrophoresis (CE) and related techniques yield highly efficient separations while requiring only minute amounts of sample. Thus, these techniques are amenable to analyses of complex samples in diverse matrices and in situations where sample is extremely limited. The constraints of on‐column detection generally result in poor detection limits and have reduced the overall application of CE. One logical approach to increased sensitivity in CE detection has been the development of chemiluminescence (CL)‐based detectors. The current state of post‐column detector development, CL applications, and limitations of the technique are reported herein.