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Electrochemical detection in capillary electrophoresis
Author(s) -
Voegel Phillip D.,
Baldwin Richard P.
Publication year - 1997
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150181217
Subject(s) - capillary electrophoresis , analyte , decoupling (probability) , electrode , electrochemistry , capillary action , chemistry , nanotechnology , instrumentation (computer programming) , computer science , chromatography , combinatorial chemistry , materials science , engineering , control engineering , operating system , composite material
Recent advances in the design and application of electrochemical detection (EC) systems in capillary electrophoresis (CE) are reviewed, with the objective of providing the non‐electrochemist with a state‐of‐the‐art picture of CEEC instrumentation and an overview of the primary analytes and samples for which the technique is best suited. In particular, instrument innovations designed to aid in decoupling the CE and EC systems electrically and in aligning them physically are described in detail. In addition, CEEC applications are summarized for four specific analyte groups: catecholamines, thiols and disulfides, amino acids, and carbohydrates. On this basis, it is clear that EC techniques have reached a stage where they are already having a significant impact on CE usage in selected areas of analysis. Continued developments with respect to new electrode materials and electrode configurations promise to broaden this impact further.