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Linkage analysis of bronchial hyperreactivity and atopy with chromosome 11q13
Author(s) -
Wong Zilla Y. H.,
Tsonis Dina,
van Herwerden Lynne,
Raven Joan,
Forbes Andrew,
Abramson Michael J.,
Walters E. Haydn,
Harrap Stephen B.
Publication year - 1997
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150180928
Subject(s) - atopy , linkage (software) , genetic linkage , asthma , microsatellite , genetics , immunoglobulin e , chromosome , sibling , biology , immunology , gene , antibody , psychology , developmental psychology , allele
There are two key clinical features of asthma: allergy and bronchial hyperreactivity (BHR). Some pedigree studies of atopy have indicated linkage with the high affinity IgE receptor (FcϵRI‐β) gene on chromosome 11q13, but others failed to confirm this linkage. We examined the genetic linkage of three polymorphic microsatellite markers to atopy and BHR in 120 affected sibling pairs recruited from the general community. We found no linkage to atopy at any of the three 11q13 loci studied. Our findings also do not favour linkage between BHR and loci approximately 8–9 cM either side of the FcϵRI‐β gene.