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A paternity case with apparently conflicting multilocus and single‐locus DNA typing results
Author(s) -
Kühnau Wolfgang,
Böhm Ingolf,
Krawczak Michael,
Schmidtke Jörg
Publication year - 1997
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150180919
Subject(s) - genetics , biology , locus (genetics) , dna profiling , variable number tandem repeat , minisatellite , typing , dna , computational biology , microsatellite , allele , gene
A paternity case is presented in which DNA typing with thirteen variable number of tandem repeat (VNTR) systems was in apparent conflict with an initial multilocus DNA analysis using oligonucleotide probe (CAC) 5 . A dual approach was necessary, because the multilocus analysis yielded a proportion of aberrant nonmaternal offspring bands far too small and level of band‐sharing too high for non‐paternity. The case could finally be solved by reference to the joint likelihood ratio combining both approaches. Arguments are presented that summation of log likelihoods is indeed valid even if no information is available regarding linkage between the VNTR loci and the loci contributing to a multilocus DNA fingerprint.