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Separation of synthesized enantiomers and diastereomers of thiino‐[4,3‐ b ]pyrrole‐2,3‐dione derivatives and 2 H ‐thiopyrans by capillary electrophoresis
Author(s) -
Blitzke Thorsten,
Wilde Horst,
Vogt Carla
Publication year - 1997
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150180620
Subject(s) - diastereomer , enantiomer , chemistry , capillary electrophoresis , chromatography , resolution (logic) , cyclodextrin , pyrrole , micelle , analyte , organic chemistry , aqueous solution , artificial intelligence , computer science
Capillary electrophoresis was used to separate diastereomers and enantiomers of synthesized thiopyrans and thiinopyrroles. Separation conditions were optimized by varying the buffer parameters, i.e. , kind and concentration of chiral selector, pH, main buffering component, micelle forming additives, and content of organic solvents. The interaction of thiopyrans and thiinopyrroles with β‐ and γ‐cyclodextrins results in the separation of enantiomers and diastereomers. The magnitude of the resolution depends on the spatial requirements of the different substituents of the analytes and the dimensions of the cyclodextrin cavity. For well‐separated enantiomers or diastereomers the identification and characterization of degradation products was possible.