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Acute‐phase proteins in perinatal human plasma
Author(s) -
Liberatori Sabrina,
Bini Luca,
De Felice Claudio,
Magi Barbara,
Marzocchi Barbara,
Raggiaschi Roberto,
Pallini Vitaliano,
Bracci Rodolfo
Publication year - 1997
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150180331
Subject(s) - haptoglobin , acute phase protein , serum amyloid a , sepsis , blood proteins , medicine , amyloid (mycology) , chemistry , immunology , endocrinology , biology , andrology , inflammation , pathology
Plasma from eight newborns (4 pre‐term and 4 full‐term) with early‐onset (<72 h) sepsis and six apparently healthy controls was analyzed. The presence of spots identified as haptoglobin and serum amyloid A protein was the electrophoretic result most consistently associated with disease. Time course monitoring showed rises, peaks and declines of spot intensity as expected for acute‐phase proteins induced by transient stimuli. Haptoglobin β chains appear to be undersialated in pre‐term newborns, whereas post‐translational modifications of α chains and serum amyloid A protein are similar to those observed in adults. The undersialation of β chain and occurrence of α chain phenotypes different from those found in maternal serum indicate that perinatal haptoglobin originates from neonatal synthesis.